Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease
Identifieur interne : 001738 ( Main/Exploration ); précédent : 001737; suivant : 001739Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease
Auteurs : Reed F. Johnson [États-Unis] ; Laura E. Via [États-Unis] ; Mia R. Kumar [États-Unis] ; Joseph P. Cornish [États-Unis] ; Srikanth Yellayi [États-Unis] ; Louis Huzella [États-Unis] ; Elena Postnikova [États-Unis] ; Nicholas Oberlander [États-Unis] ; Christopher Bartos [États-Unis] ; Britini L. Ork [États-Unis] ; Steven Mazur [États-Unis] ; Cindy Allan [États-Unis] ; Michael R. Holbrook [États-Unis] ; Jeffrey Solomon [États-Unis] ; Joshua C. Johnson [États-Unis] ; James Pickel [États-Unis] ; Lisa E. Hensley [États-Unis] ; Peter B. Jahrling [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Anticorps antiviraux (immunologie), Biopsie, Callithrix, Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Indice de gravité médicale, Infections à coronavirus (médecine vétérinaire), Maladies des singes (diagnostic), Maladies des singes (immunologie), Maladies des singes (mortalité), Maladies des singes (virologie), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Rein (anatomopathologie), Rein (virologie), Tomodensitométrie.
- MESH :
- anatomopathologie : Poumon, Rein.
- diagnostic : Maladies des singes.
- génétique : ARN viral.
- immunologie : Anticorps antiviraux, Maladies des singes.
- mortalité : Maladies des singes.
- médecine vétérinaire : Infections à coronavirus.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Maladies des singes, Poumon, Rein.
- Animaux, Biopsie, Callithrix, Cellules Vero, Indice de gravité médicale, Modèles animaux de maladie humaine, Tomodensitométrie.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), Biopsy, Callithrix, Chlorocebus aethiops, Coronavirus Infections (veterinary), Disease Models, Animal, Kidney (pathology), Kidney (virology), Lung (pathology), Lung (virology), Middle East Respiratory Syndrome Coronavirus (physiology), Monkey Diseases (diagnosis), Monkey Diseases (immunology), Monkey Diseases (mortality), Monkey Diseases (virology), RNA, Viral (genetics), Severity of Illness Index, Tomography, X-Ray Computed, Vero Cells.
- MESH :
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Viral.
- diagnosis : Monkey Diseases.
- immunology : Monkey Diseases.
- mortality : Monkey Diseases.
- pathology : Kidney, Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Kidney, Lung, Monkey Diseases.
- Animals, Biopsy, Callithrix, Chlorocebus aethiops, Disease Models, Animal, Severity of Illness Index, Tomography, X-Ray Computed, Vero Cells.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication.
Url:
DOI: 10.1016/j.virol.2015.07.013
PubMed: 26342468
PubMed Central: 5001852
Affiliations:
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Le document en format XML
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<author><name sortKey="Mazur, Steven" sort="Mazur, Steven" uniqKey="Mazur S" first="Steven" last="Mazur">Steven Mazur</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allan, Cindy" sort="Allan, Cindy" uniqKey="Allan C" first="Cindy" last="Allan">Cindy Allan</name>
<affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holbrook, Michael R" sort="Holbrook, Michael R" uniqKey="Holbrook M" first="Michael R." last="Holbrook">Michael R. Holbrook</name>
<affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Solomon, Jeffrey" sort="Solomon, Jeffrey" uniqKey="Solomon J" first="Jeffrey" last="Solomon">Jeffrey Solomon</name>
<affiliation wicri:level="2"><nlm:aff id="aff0020">Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Joshua C" sort="Johnson, Joshua C" uniqKey="Johnson J" first="Joshua C." last="Johnson">Joshua C. Johnson</name>
<affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pickel, James" sort="Pickel, James" uniqKey="Pickel J" first="James" last="Pickel">James Pickel</name>
<affiliation wicri:level="2"><nlm:aff id="aff0025">Transgenic Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Transgenic Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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</affiliation>
</author>
<author><name sortKey="Hensley, Lisa E" sort="Hensley, Lisa E" uniqKey="Hensley L" first="Lisa E." last="Hensley">Lisa E. Hensley</name>
<affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahrling, Peter B" sort="Jahrling, Peter B" uniqKey="Jahrling P" first="Peter B." last="Jahrling">Peter B. Jahrling</name>
<affiliation wicri:level="2"><nlm:aff id="aff0005">Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff0015">Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<idno type="eISSN">1096-0341</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (immunology)</term>
<term>Biopsy</term>
<term>Callithrix</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Disease Models, Animal</term>
<term>Kidney (pathology)</term>
<term>Kidney (virology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Monkey Diseases (diagnosis)</term>
<term>Monkey Diseases (immunology)</term>
<term>Monkey Diseases (mortality)</term>
<term>Monkey Diseases (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>Severity of Illness Index</term>
<term>Tomography, X-Ray Computed</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Biopsie</term>
<term>Callithrix</term>
<term>Cellules Vero</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Indice de gravité médicale</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Maladies des singes (diagnostic)</term>
<term>Maladies des singes (immunologie)</term>
<term>Maladies des singes (mortalité)</term>
<term>Maladies des singes (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Rein (anatomopathologie)</term>
<term>Rein (virologie)</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
<term>Rein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Monkey Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladies des singes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Maladies des singes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Monkey Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Monkey Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Maladies des singes</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Kidney</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies des singes</term>
<term>Poumon</term>
<term>Rein</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Kidney</term>
<term>Lung</term>
<term>Monkey Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biopsy</term>
<term>Callithrix</term>
<term>Chlorocebus aethiops</term>
<term>Disease Models, Animal</term>
<term>Severity of Illness Index</term>
<term>Tomography, X-Ray Computed</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Biopsie</term>
<term>Callithrix</term>
<term>Cellules Vero</term>
<term>Indice de gravité médicale</term>
<term>Modèles animaux de maladie humaine</term>
<term>Tomodensitométrie</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication.</p>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
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</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Johnson, Reed F" sort="Johnson, Reed F" uniqKey="Johnson R" first="Reed F." last="Johnson">Reed F. Johnson</name>
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</affiliations>
</record>
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